Anticancer Potential of Ethyl Acetate Extract Fractions of Ipomoea horsfalliae Hook on DMBA- Induced Breast Cancer Model

Abstract

The genus Ipomoea is distributed globally and honored as the largest genus of the family Convolvulaceae. Several varieties of this family have been shown to be effective in treating various diseases, including cancer. This research aimed to explore the anticancer activity of ethyl acetate fractions of Ipomoea horsfalliae Hook (EAIH) in female Sprague-Dawley rats. 7, 12-dimethylbenz (a) anthracene (DMBA) was used to produce breast cancer. The Fractions were selected based on the cytotoxicity analysis in vitro, which was reported in our earlier studies. The study employed two dosages of EAIH (25 and 50 mg/kg). Biochemical, hematological, and antioxidant characteristics were investigated. A decrease in mean tumor volume and tumor weight was detected in EAIH treated groups. The blood parameters were seen as normal. In both DMBA and doxorubicin groups, malondialdehyde was increased, and the level was significantly reduced in EAIH-treated groups. The effect of catalase was shown to be diminished in the groups given DMBA and doxorubicin but normal in the EAIH groups. Nitrate and nitrite levels increased in the DMBA control groups but were normal in the others. There was less necrosis and infiltration in breast tissues treated with doxorubicin as well as in EAIH. In animals treated with EAIH, the therapeutic effect was found to be dose-dependent. The therapies helped to repair some of the altered breast patterns. The study concludes that I. horsfolliae may be a potential anticancer candidate and need to explore further.