Abstract
Herein we describe the synthesis of 2-((E)-(2-(benzo[d]thiazol-2-yl)phenylimino)methyl)-5-methoxyphenol imine base (BMM) and its metal complexes such as [Co(BMM)2] C1, [Co(BMM)(ph)] C2, [Ru(BMM)2] C3 and [Ru(BMM)(ph)] C4. The ligand and its complexes were characterized by spectroscopic, TGA, Powder X-ray diffraction (XRD), and elemental analysis. The coordination number and geometry were confirmed by various experimental data. The Co(III) and Ru(III) complexes are assigned to be having octahedral geometry. Further, the experimental results revealed that complex C2 and C4 emerged as moderate DNA binding intercalators compared to standard intercalators and prominent nuclease activity compared with C1 and C3 complexes. The extent of interaction and intercalation mode was confirmed by monitoring electronic absorption studies, fluorescence quenching probe, and viscosity measurement. Furthermore, the complexes C1-C4 were investigated for their in vitro cytotoxic studies against a panel of human cancer cell lines, viz., A549, NIH3T3, MCF-7, and EAC. Also, the cell adhesion and migration behavior were carried out after administering the complex C2 and C4 to respective cancer cell lines. In mice, the toxicities and tolerabilities of the complex C2 and C4 were also investigated through in vivo studies. The resultant complexes were screened for their microbial inhibition studies through the good diffusion method. All the complexes display moderate microbial inhibition properties compared to their uncoordinated analog.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Structural and antimicrobial activity studies of brand new benzothiazole-pyrazole conjugates;Journal of Molecular Structure;2025-01
2. Molecular modeling and antimicrobial activity of newly synthesized benzothiazole-thiazole conjugates;Journal of Photochemistry and Photobiology A: Chemistry;2024-11
3. Co(III), Ni(II), Pd(II) and Pt(II) complexes derived from new benzimidazole-based imine ligands: Preparation, structure, antibacterial, HSA binding and DNA interaction studies;Inorganica Chimica Acta;2024-05
4. Synthesis, structure, and in vitro biological studies of benzothiazole based Schiff base ligand and its binary and ternary Co(III) and Ni(II) complexes;Inorganica Chimica Acta;2024-01
5. Preparation, spectroscopic characterization and activity study using a new (N, N, O) Azo-Schiff base ligand derived from 2-amino-5-methyl thiazol and its utilization in dyeing;AIP Conference Proceedings;2024