Anti COVID-19 Drug – Potential Bioactive Compounds from Sprout Shoots of Curcuma longa Rhizome and Molecular Interaction Studies

Abstract

India is currently fighting against the deadly contagious, Novel coronavirus (nCoV) in all possible means. Though many antiviral drugs are available in the mainstream treatment for respiratory viral infections, no targeted antiviral has been identified, and vaccine trials are ongoing. The traditional system of medicine possesses a broad range of scope to bridge the gaps in treatment methods and the time lag between vaccine developments. There may be a chance of mutation of the virus, drug resistance, etc. The present study reports metabolites profiling from the shoot of Curcuma longa, and the LCMS method was used to characterize phytochemical in which sixteen compounds were screened and used for the active site of the SARS CoV-2 spike protein using Autodock 4.2.6. The three dimensions crystal structure PDB id was retrieved from PDB, and the active sites were predicted using metapocket 2.0. Binding affinity data and interaction patterns revealed that these compounds could inhibit the development of disease inside the body system, and it can be used to design different nutraceutical and pharmaceuticals.