Ovothiol-A Isolated from Sea Urchin Eggs Suppress Oxidative Stress, Inflammation, and Dyslipidemia Resulted in Restoration of Liver Activity in Cholestatic Rats

Abstract

Cholestasis is dropping in bile flow, leading to the intrahepatic bulk of bile acids and other poisonous compounds with the progression of liver pathology, including hepatocellular injury and fibrosis. Ovothiols extracted from sea urchin display unusual antioxidant properties due to the peculiar position of the thiol group on the imidazole ring of histidine. The present study aims to evaluate the anti-fibrotic effect of Ovothiol-A in rats. 28 rats were allocated randomly into 4 groups: Sham, BDL, and BDL + Ovothiol A (500 mg/kg). All rats were treated for 7 days. Oxidative stress biomarkers, liver functions, lipid profile, and histology were all examined. The results revealed that BDL operation induced oxidative stress in rats, which negatively impacted liver functions, as confirmed by the histopathological examination. Ovothiol-A has been shown to lower oxidative stress and enhance lipid profile, resulting in considerable improvements in most biochemical markers. Also, histopathological examination showed an improvement in the liver architecture of the treated group compared to the BDL group. Ovothiol-A protects the liver against toxicity results from cholestasis in rats.