Pharmacodynamics Interaction of Quercetin and Captopril on Doxorubicin Induced Myocardial Toxic Rats

Abstract

Captopril (CAP), an ACE inhibitor, is widely used in the therapy of cardiovascular disease. Quercetin (QUE), a plant-derived flavonol that exerts cardioprotective activity through its antioxidant mechanism. A combination of CAP and QUE may produce synergistic or antagonistic cardioprotective effects. Therefore, the present study was designed to evaluate the pharmacodynamics interaction of QUE and CAP in Doxorubicin (Dox) induced oxidative myocardial damage in rats. Rats were pretreated with normal saline, QUE (10 mg/kg), and CAP (30 mg/kg) alone and in combination orally for 14 days. On the 14th day of treatment, rats were injected with Dox (10mg/kg single dose i.p) for the induction of myocardial damage. There was a substantial fall and rise in activities of marker enzymes such as CK-MB, LDH, AST, and ALT in serum and elevation of ST-segment, increased QT interval, and HR upon Dox administration. Pretreatment with QUE and CAP alone significantly restored the above parameters. But, the Concomitant pretreatment with QUE and CAP was found to be less significantly restored the Dox-induced alterations. The present study suggests that concomitant pretreatment with CAP and QUE could attenuate cardiovascular protection than that of alone pretreatment. It may be due to the antagonistic effect between the two drugs.