Synthesis, Antimicrobial, Antiproliferative, and Docking Studies of 1,3,4-Oxadiazole Derivatives Containing Benzimidazole Scaffold

Abstract

Due to chemotherapy failure, drug resistance, and the advent of multiresistant microbes, new antimicrobial and anticancer agents are needed. The present study has synthesized and screened new 1,3,4-oxadiazole derivatives bearing benzimidazole scaffold for antimicrobial and anticancer activities. The structure of final compounds 8-15 was completely established by NMR (1H, 13C), mass, IR, and elemental analysis. From the antimicrobial study, compounds10 and 15 exhibited promising effects against Gram-positive bacterial strains, S. aureus, and S. epidermidis, with MIC comparable to standard drugs. Also, the same compounds 10 and 15 displayed potent cytotoxicity against MCF-7 breast carcinoma, which was comparable to doxorubicin. Furthermore, docking studies have been performed to explore the binding interaction of the compounds with the target protein.