An Overview on the Pathophysiological Roles of microRNA- 802: a Literature Review

Abstract

Over the last two decades, microRNAs (miRNAs) have emerged as a novel class of small non-coding RNAs that fine-tune the expression of various target genes at a post-transcriptional level. Recent studies have highlighted the functional roles of miR-802 in different pathological and physiological conditions. By means of different molecular techniques, including high throughput and gene silencing ones, miR-802 aberrant expression and some of its targets and mechanisms of action have been determined in obesity, glucose metabolism, different types of cancers, Down syndrome, nephropathy, and immune system-mediated conditions. Herein, we review the current knowledge about promising applications of miR-802 in human diseases as biomarkers and therapeutic targets.