Electrochemical Sensing of Uric Acid and Guanine Using a Graphite Paste Electrode of NiMn2O4 Spinel Nanoparticles

Abstract

Guanine (GU) and uric acid (UA) each have their biological significance as an indicator and cause various serious disorders in the human body. Therefore, sensing their level in the human fluid is of paramount importance in monitoring serious human physiology disorders. In this regard, we developed an efficient electrochemical sensor from nanoparticles of nickel magnate (NPs-NiMn2O4) incorporated with graphite paste (NiMn2O4-NPs /GP) to detect both the GU and UA individually and simultaneously. Cyclic voltammetric (CV) and differential pulse voltammetric (DPV) techniques were employed to examine the electrochemical sensing ability of the NiMn2O4-NPs/GP sensor. The findings revealed that the detection limits of UA and GU were 400 and 400 Nm with linear ranges from 3.0 to 120 µM and 0.5 to 100 µM, respectively. Further, the influence of scan rate and pH of electrolyte on the sensing ability of prepared sensor was also systematically investigated.