Preparation and Antibacterial Activity of New Iodine-Containing Materials based on Pectin Modified with Pharmacologically Active Acids

Abstract

A new approach has been developed for obtaining stable iodine-containing powders based on pectins modified with pharmacologically active (nicotinic, salicylic, 5-aminosalicylic, anthranilic) acids. A set of methods (IR-, UV-, 13C NMR-spectroscopy, elemental, thermogravimetric analysis, viscometry, polarimetry, electron microscopy) were used to characterize the physicochemical properties of iodine-containing compositions. It has been established that the modification of pectin with organic pharmacophores leads to an increase in the iodine content in the modified samples by 4-7 times and makes it possible to obtain compounds not only with a high iodine content from 30 to 60 % but also with its controlled and prolonged release. Furthermore, according to the results of microbiological tests against soil bacteria Bacillus megaterium, Pseudomonas aureofaciens, and lactic acid bacterium Lactococcus lactis, a high antibacterial activity of the obtained iodine-containing materials was established.