Protective Role of Combined Crataegus Aronia Ethanol Extract and Phytosomes Against Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced Diabetic Rat

Abstract

Diabetes is one of the most common chronic diseases worldwide. This study aims to evaluate the hypoglycemic and hypolipidemic effects of Crataegus aronia (C. aronia) ethanolic extract and Crataegus aronia phytosome (C. aronia-p) in streptozotocin (STZ)-induced diabetic rats. The phytochemical content of C. aronia was identified. The C. aronia ethanolic extract and C. aronia-p were checked for their antioxidant activity using DPPH assay. Then, in vivo evaluation of C. aronia ethanolic extract and C. aronia-p hypolipidemic and hypoglycemic activity was conducted using STZ-induced diabetic rats. The major phytochemicals component found in C. aronia ethanolic extract is phenols, flavonoids, alkaloids, and tannins. Moreover, The IC50 of DPPH scavenging activity after the treatment of C. aronia leaf ethanolic extract is 69.46±6.4 μl. Furthermore, our study indicated that the C. aronia leaves extract and C. aronia-p has significant hypolipidemic and hyperglycemic activity in the diabetic rats (P <0.001). This study provides a useful indication for promoting C. aronia as a potential novel therapeutic agent against diabetes.