Expatiating the Therapeutic Profile of Garlic (Allium sativum): a Bench to Bedside Approach

Abstract

Garlic (Allium sativum) is amongst the oldest medicinal plant in centuries. It is an amazing plant that contains numerous bioactive components such as organosulfur compounds, allicin, s-allyl cysteine, S-allyl-mercapto cysteine, diallyl sulfide, diallyl disulfide, and diallyl trisulfide. This review discusses numerous valuable effects and therapeutic potential of garlic in treating several diseases such as cancer, obesity, diabetes, liver injury, hypertension, inflammation, viral infection, and arthritis. The enormous immunomodulatory, anti-oxidant, and anti-microbial characteristics of garlic have also been explained briefly. This review article also gives insight into the nanotechnology-based phytopharmaceuticals of garlic; has summarized pre-clinical models, clinical trials, and patents published about garlic's therapeutic applications and its phytoconstituents in the management of several disease conditions. This review article brings more attention to garlic, providing effective scientific proof for improved utilization of garlic in human health and disease control.