Abstract
Based on the Knoevenagel condensation, nitrosation, and azo coupling reactions, the synthesis of some С5 substituted 4-phenylimino-thiazolidin-2-ones was carried out. The chemical structures of the synthesized products have been determined by 1H NMR spectroscopy and elemental analysis. Evaluation of novel compounds over the carrageenan-summoned rat paw edema revealed a powerful anti-inflammatory effect of some substances which exceeds the activity of the comparative drug Ibuprofen.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology
Cited by
11 articles.
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