Hydroxycoumarin Grafted with Hydrazine: Synthesis, Structure Elucidation and Assessment of Antioxidant and Antibacterial Characteristics

Abstract

4-Hydroxycoumarin, as a natural organic compound, was structurally grafted onto a benzaldehyde by hydrazine. The chemical structure of grafted macromolecule was confirmed by FT-IR and NMR spectroscopy. The antibacterial activity of the synthesized grafted macromolecule against Staphyloccocus aureus, E. coli, Proteus vulgaris, Pseudomonas, and Klebsiella pneumoniae was assessed using a disc diffusion technique. The antioxidant activity of the grafted macromolecule was also highlighted using the superoxide-radical technique. The grafted macromolecule has high inhibition activity against all tested bacteria. The grafted macromolecule was a much more effective free radical scavenger than vitamin C.