Assessment of Tumor Take Inhibitory Activity of Ethanolic Leaf Extract of Piper betle L. in Mice

Abstract

The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Piper betle in rodents. Tumor takes inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at a dose of 50mg/kg body weight, i.p. for 10 consecutive days. The animals were observed to grow tumors after injection of B16F10 melanoma cells into mice's dorsal skin. Pretreatment with the extract and showed delays in tumor growth by increasing the volume doubling time, VDT (p<0.01), growth delay, GD (p< 0.01), and mean survival time, MST (p<0.001). Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma tumor cell lines, demonstrated by increasing the VDT and GD.