Fabrication of Dexamethasone-Silver Nanoparticles Entrapped Dendrimer Collagen Matrix Nanoparticles for Dental Applications

Author:

Abstract

A bioengineered tooth is a well-studied subject. However, it is a challenge when seamless integration of various functionalities is required. In the case of teeth, integrating stem cell differentiating agents, regenerating the dentin tissue, and arresting the biofilm formation are three aspects that call for attention. Dental pulp stem cell differentiation to odontoblasts can be facilitated by dexamethasone (Dex). The ideal scaffold for regeneration applications – collagen (Col), has several advantages but also has no inherent rigidity. Silver nanoparticles (AgNps) are found to be an ideal material for preventing biofilm formation, with challenges arising from their stability and cytotoxicity. The route was chosen based on the successful demonstration of various platforms is the PAMAM (Den) dendrimers. The platform encompassing all the ingredients – AgNp@Den@Dex@Col had a max at 622 nm. FTIR studies revealed the presence of all components, and scaffold degradation temperature improved. A linked morphology was observed under TEM, and the zone of inhibition (MIC) was 3.5 mm, indicating good antibacterial activity. There was also a 60% reduction in biofilm formation against Staphylococcus aureus and 40% against Klebsiella pneumoniae by the fabricated nanocomposite AgNp@Den@Dex@Col. In essence, this work reports a platform where three functions of stem cell differentiation, regeneration, and biofilm formation are integrated.

Publisher

AMG Transcend Association

Subject

Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Silver-dendrimer nanocomposite as emerging therapeutics in anti-bacteria and beyond;Drug Resistance Updates;2023-05

2. The role of nanocomposites against biofilm infections in humans;Frontiers in Cellular and Infection Microbiology;2023-02-28

3. Dendrimers in drug delivery;Advanced and Modern Approaches for Drug Delivery;2023

4. Inorganic Nanoparticles in Bone Healing Applications;Pharmaceutics;2022-03-31

5. Enhanced Antibacterial and Anti-Biofilm Activities of Antimicrobial Peptides Modified Silver Nanoparticles;International Journal of Nanomedicine;2021-07

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