High Transverse Relaxivity and Anticancer Agent Loading/Release Characteristics of Porous Calcium Phosphate Coated Iron Oxide Nanoparticles

Author:

Abstract

High relaxivity of MRI contrast agents leads to considerable contrast enhancement in the images and provides diagnostic accuracy. The purpose of the current study was to design a potential MRI contrast agent with a high relaxivity and investigate its curcumin loading/release property. To achieve this purpose, we synthesized the porous calcium phosphate coated iron oxide nanoparticles using a facile method and determined the physicochemical characteristics, cell compatibility effect, transverse relaxivity, and curcumin loading/release properties of the nanoparticles. The results indicated the spherical nanoparticles with a size of 10-20 nm. The nanoparticles demonstrated a superparamagnetic property and a high transverse relaxivity of 845.71 mM-1S-1. Although the porous calcium phosphate coated iron oxide nanoparticles were highly cytocompatible, the curcumin loaded nanoparticles showed a considerable effect on the bone marrow stem cells viability. In conclusion, the porous calcium phosphate coated iron oxide nanoparticles have the potential to introduce as a negative contrast agent of MRI with the ability of slow release of curcumin.

Publisher

AMG Transcend Association

Subject

Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology

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