Design and Synthesis of a Lactam-Steroid Derivative and their Theoretical Interaction with a SAR-COV2
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Published:2020-07-03
Issue:1
Volume:11
Page:7621-7631
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ISSN:2069-5837
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Container-title:Biointerface Research in Applied Chemistry
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language:en
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Short-container-title:Biointerface Res Appl Chem
Abstract
Several drugs have been developed for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents that are dangerous and require special conditions. The objective of this research was to synthesize a Lactam-steroid derivative to evaluate its theoretical interaction with SARS-CoV using at 6LU7-protein as a theoretical model. Furthermore, this interaction was carried out in a docking model using hydroxychloroquine and favipiravir as controls. The results showed that the binding energy involved in the interaction of the lactam-steroid derivative with 6LU7 protein surface was lower compared with both hydroxychloroquine and favipiravir. In conclusion, the lactam-steroid derivative could be an alternative therapeutic to treatment of SARS-CoV.
Publisher
AMG Transcend Association
Subject
Molecular Biology,Molecular Medicine,Biochemistry,Biotechnology
Cited by
1 articles.
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