Design and Synthesis of a Lactam-Steroid Derivative and their Theoretical Interaction with a SAR-COV2

Abstract

Several drugs have been developed for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV) using different protocols; however, some methods use different reagents that are dangerous and require special conditions. The objective of this research was to synthesize a Lactam-steroid derivative to evaluate its theoretical interaction with SARS-CoV using at 6LU7-protein as a theoretical model. Furthermore, this interaction was carried out in a docking model using hydroxychloroquine and favipiravir as controls. The results showed that the binding energy involved in the interaction of the lactam-steroid derivative with 6LU7 protein surface was lower compared with both hydroxychloroquine and favipiravir. In conclusion, the lactam-steroid derivative could be an alternative therapeutic to treatment of SARS-CoV.