Targeted Regulation of Intracellular Signal Transduction in Regeneration-Competent Cells: A new Direction for Therapy in Regenerative Medicine

Abstract

A scientific and theoretical justification for developing the original direction for targeted therapy in regenerative medicine - "Strategy of pharmacological regulation of intracellular signal transduction in regeneration-competent cells" is presented. It is proposed to use intracellular signaling molecules, which play an important role in regulating the proliferative and differentiation status of progenitors and microenvironment cells, as targets of drugs with regenerative activity. The selectivity of stimulation of the regeneration of individual tissues is determined by the peculiarities of intracellular signaling in different progenitor cells and/or tissue-specific expression of certain types and isoform signaling molecules. The results of their basic research on the role of some signaling molecules (potential targets) in regulating the cell cycle of the progenitors of different types and the functioning of the tissue microenvironment cells are given. Experimental models of some pathological conditions (CNS, skin, and hematopoietic tissue) show the effectiveness of implementing the proposed concept of pharmacotherapy. The results are fundamental to the creation of novel targeted drugs for the treatment of degenerative diseases.