In silico Analysis of Quercetin and its Analogues Against Targeted Proteins

Abstract

Quercetin is a flavonoid compound present in many plants such as onions, tomatoes, apples, green tea, flax seeds, etc. It possesses antioxidant and anti-inflammatory effects that help control inflammation, kill cancer cells, and prevent heart disease. Wide evidence reveals quercetin's antitumor property to inhibit various cancers like breast, lung, nasopharyngeal, kidney, colorectal, pancreatic, prostate, and ovarian cancer. In this study, quercetin was docked against proteins such as Apoptic protein (APAF-1, BAX, BCL-2), Heat shock protein, Cytochrome p45O, Actin, Tyrosine-protein kinase hck. From the Insilico research completed, we can infer that quercetin and the analogs show great efficacy in finding against cancer and can be used in cancer care. These findings will help us understand the quercetin's binding ability with proteins and know-how quercetin is involved in the anti-cancer, antioxidant role.