Affiliation:
1. Ural State Medical University
2. Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences
3. I. Ya. Postovsky Insititute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Abstract
Introduction. Acute post-manipulation pancreatitis (APP) is a common complication of endoscopic interventions on the major duodenal papilla of the duodenum. Moderate acute pancreatitis develops more often than severe acute pancreatitis.The purpose of the work is to determine the effect of compound L-17 of the group of substituted thiadiazines on the severity of the inflammatory reaction in moderate severity APP.Materials and methods. The severity of the inflammatory reaction in experimental APP after surgery in rats using the compound L-17 was studied. During this study, laboratory indicators of the severity of the inflammatory reaction were assessed, including the leukocyte count and the level of increase in the concentration of the major interleukins. Furthermore, morphological data was analyzed to allow an assessment of the dynamics of the cellular composition of the inflammatory infiltrate of the pancreas in the APP in the experiment.Results. A decrease in the severity of the inflammatory reaction was shown according to leukocyte count, cytokine concentration, and a morphological study of the inflammatory infiltrate of the pancreas.Discussion. The effectiveness of the proposed surgical technique for the formation of APP has been proven by the development of acute pancreatitis in all animals operated. Most experimental methods for acute pancreatitis have no such effectiveness. The data obtained confirm the opinion of numerous authors that interventions on the major duodenal papilla are a risk factor for the development of APP. The study used the compound L-17, which is a representative of a new group of organic compounds, substituted thiadiazines, which have a disaggregant and anticoagulant effect. The effect of compound L-17 on the hemocoagulation parameters of blood is associated with the anti-inflammatory mechanism of action of compound L-17.Conclusion. Administration of compound L-17 in moderate-severity experimental APP can reduce the severity of the inflammatory reaction.
Publisher
Ural State Medical University
Reference36 articles.
1. Revishvili ASh, Kubyshkin VA, Zatevahin II, Bagnenko SF, Polushin YuS, Maistrenko NA, et al. Acute Pancreatitis. Moscow; 2020. 54 p. EDN: https://elibrary.ru/epwodt.
2. Karyampudi A, Nabi Z, Reddy DN. Risk factors and prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis: An update. EMJ. 2021;6(4):96–108. Available from: https://clck.ru/389pRq [accessed 15 October 2023].
3. Akshintala VS, Goenka MK, Kamal A, Rai VK, Ghosh S, Talukdar R, et al. Sa1386 risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis in high-risk patients: Secondary analysis of a randomized controlled study. Gastrointestinal Endoscopy. 2017;85(5 Suppl):AB219–AB220. DOI: https://doi.org/10.1016/j.gie.2017.03.489.
4. Cahyadi O, Tehami N, de-Madaria E, Siau K. Post-ERCP pancreatitis: Prevention, diagnosis and management. Medicina. 2022;58(9):1261. DOI: https://doi.org/10.3390/medicina58091261.
5. Lin Y, Liu X, Cao DQ, Tang JH, Wen JJ, Li TF, et al. Analysis of risk factors and prevention strategies of post-ERCP pancreatitis. European Review for Medical and Pharmacological Sciences. 2017;21(22):5185–5190. DOI: https://doi.org/10.26355/eurrev_201711_13838.