Effects of Neoadjuvant Chemotherapy on Reccurent Survival in Stomach Cancer

Abstract

Introduction. Integrated approach — modern standard of treatment of stomach cancer. At the same time, it is necessary to assess the influence of chemotherapy on the pre-operative stage to the distant results of treatment in real practice.The purpose of the study — determine the impact of neoadjuvant chemotherapy on patient survival.Material and methods. A retrospective study of 612 patients receiving neoadjuvant chemotherapy in the conditions of Sverdlovsk Regional Oncological Center was conducted from January 2021 to December 2023.Results and discussion. The study found that neoadjuvant chemotherapy does not affect overall survival and diseasefree overall survival compared to adjuvant, does not increase the risk of postoperative complications and mortality. Findings suggest that more careful selection of patients is needed who require neoadjuvant chemotherapy, taking into account the somatic status associated with associated pathology.Conclusion. Based on our findings, we can state that neoadjuvant chemotherapy as part of perioperative chemotherapy is the standard of patient treatment of gastric cancer II–III stage.