Affiliation:
1. Russian University of Sports “GTSOLIFK”
2. Center for Sports Innovative Technologies and training of National Teams
Abstract
Ashwagandha dietary supplement has become popular among Russians. Information about side effects associated with Ashwagandha supplementation is available in case reports and case series, although none may be available.Objective. To conduct a systematic review of clinical case reports and case series on suspected liver damage caused by Ashwagandha.Methods. The study was conducted in accordance with the statement of preferred reporting rates for systematic reviews and meta-analyses. This review considered articles published between December 2018 and December 2023.Several scientific databases were used for the systematic search: PubMed, Science Direct and Google Scholar. The level of evidence of included studies was classified using the Oxford Centre for Evidencebased Medicine level of evidence.Results. A total of 76 references were identified in the databases, 11 studies were included in the review during the screening procedure.Conclusions. We thus present 23 cases of drug-induced liver injury caused by Ashwagandha, with similar liver injury patterns and outcomes.