Role of molecular genetic non-invasive laboratory diagnostics in prevention of RH-conflict pregnancy

Author:

Khabarov S. V.1,Denisova O. V.2,Devichensky V. M.3

Affiliation:

1. Medical Institute of Tula State University; Academy of Postgraduate Education of Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; VITROMED Co.

2. Academy of Postgraduate Education of Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies; DIALAB+ Co.

3. Academy of Postgraduate Education of Federal Scientific and Clinical Centre for Specialized Medical Care and Medical Technologies

Abstract

The review is devoted to the possibility of non-invasive prenatal determination of the RH-factor of the fetus in early pregnancy based on the analysis of fetal DNA circulating in the peripheral blood of a pregnant woman. Methodical approaches to the isolation and analysis of extracellular fetal DNA are considered. The assessment of medical and economic efficiency of prenatal noninvasive screening of RH-factor of the fetus in RH-negative pregnant women is given. The possibilities, limitations and prospects of using molecular genetic non-invasive laboratory methods to determine the RH-factor of the fetus are discussed.

Publisher

Alfmed LLC

Subject

Materials Chemistry,Economics and Econometrics,Media Technology,Forestry

Reference22 articles.

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