Discogenic pain

Abstract

Discogenic pain in the back presents certain difficulties both in clinical diagnosis and in understanding pathogenesis. In recent years, several significant mechanisms of the pathogenesis of this type of back pain have been disclosed. it has been shown that the key factors for its development are increased expression of the cytokine iL-1b and other inflammatory mediators, which destroy the intercellular matrix of the disc and inhibit the production of proteoglycans. Pathological angio- and neurogenesis, developing in the intervertebral disc, which normally is aneuricular and avascular, are the main pathophysiological mechanisms of discogenic pain. Based on a number of analyzed works, it can be concluded that preparations containing chondroprotectors (symptomatic slow-acting drugs in osteoarthritis, SYSADOA) are able to influence these key pathogenesis of discogenic back pain.