Placental and serum production of cytokines and relaxin in pregnant women with diabetes mellitus-Reference-Cited by-同舟云学术

Placental and serum production of cytokines and relaxin in pregnant women with diabetes mellitus

Published:2019-11-19 Issue:25 Volume:3 Page:43-45
ISSN:2078-5631
Container-title:Medical alphabet
language:
Short-container-title:Medicinskij alfavit

Author:

Krukier I. I.¹,Avrutskaya V. V.¹,Grigoriants A. A.²,Degtyaryova A. S.¹,Nikashina A. A.¹,Rozhkov A. V.³

Affiliation:

1. Rostov State Medical University

2. Stavropol State Medical University

3. Clinic No. 1 of the Federal Customs Service of Russia

Abstract

Objective of research was to study the production of serum and placental cytokines and relaxin in women with a physiological pregnancy (45) and complicated by type I diabetes mellitus (42). The research material was the placenta and serum of pregnant women, in which determined the level of cytokines TNF-α, TGF-β, IL-1β and relaxin. It has been shown that the cytokine-producing function of the placenta plays an important role in the development of that organ, and systemic production of cytokines and relaxin is of key importance in the development of endothelial dysfunction syndrome. Early diagnosis of complications in pregnant women with type 1 diabetes will make it possible to start etiopathogenetic therapy in a timely manner and makes it possible to perform adequate obstetric tactics of labor.

Publisher

Alfmed LLC

Subject

Materials Chemistry,Economics and Econometrics,Media Technology,Forestry

Reference19 articles.

1. Savel'eva G. M., Kurtser M. A., Karaganova E. Ya. i soavt. Vedenie fiziologicheskikh i oslozhnennykh rodov. Akusherstvo i ginekologiya. 2011; 3: 4–10.

2. Radzinskii V. E. Akusherskaya agressiya. M.: Izd- vo zhurnala Status Praesens, 2011; 688 s.

3. Sel'kov S., Pavlov O. Rol' matochno-platsentarnykh makrofagov v reproduktivnoi patologii. Zhurnal akusherstva i zhenskikh boleznei. 2010; 59 (1): 122–130.

4. Pogorelova T. N., Linde V. A. i soavt. Molekulyarnye mekhanizmy regulyatsii metabolicheskikh protsessov v platsente pri fiziologicheski protekayushchei i oslozhnennoi beremennosti. SPb. Gippokrat. 2012.

5. Hutching G, Williams O, Cretoiu D, et al. Myometrial interstitial cells and the coordination of myometrial contractility. J Cell Moll Med. 2009; 174: 73–77.