Long-term effects of chemotherapy in patients with acute leukemia in childhood

Abstract

An increase in the survival rate of patients who had cancer in childhood determines the need to study the long-term consequences of the treatment. Long-term complications may develop from various organs and systems: active studies of the toxicity of chemotherapy are carried out in the field of pharmacogenetics, respiratory, cardiovascular, sensorineural and endocrine systems, as well as skin, central nervous system, immune system and others. The treatment of acute leukemia carried out in childhood can significantly reduce the quality of life, cause cognitive and psychoemotional disorders. Experts in the field of pediatric hematology-oncology proposed to create an indicator called «survival without pronounced toxicity». A group of scientists initiated an international project to study the outcomes of childhood malignant tumors. Among the long-term consequences, it is planned to assess the quality of life and the development of complications. The study of long-term complications of leukemia treatment will allow us to develop algorithms for the prevention and follow-up of these patients.