Distinctive features of multidimensional relationships of hypercalcemia associated with dynamics of bone metabolism markers

Abstract

Using the author’s method for determining the multidimensional relationships of ionized calcium in personal observations in 82 patients based on the analysis of the panel of ratios of indicators of water and electrolyte metabolism, it was found that hypercalcemia in the structure of these ratios can include indicators of bone tissue metabolism, while differing in their characteristics. In the discussion, the authors cite modern literary sources that substantiate the established differences in the structure of complexes of multidimensional bonds. Also, the obtained results indicate the possibility of manifestation of signs of changes in the balance of B-cross Laps and TP1N with a high strength in combination with the influence of calcium, while maintaining the absolute values of the latter within the reference values of the norm. The authors believe that in these cases there are signs of a high functional stress of the mechanisms that contribute to maintaining analyte values within the normal range. Summarizing the results of the analysis of the selected observations, the authors believe that the mechanisms involved in the regulation of bone metabolism can be divided into two levels: local and intersystem (in particular, with the participation of leukocyte subpopulations). If the first level (primarily remodeling) weakly correlated with the influence of leukocyte subpopulations on this process, then the second, which was distinguished by significant shifts in the balance of osteosynthesis and osteolysis, included signs of activation of individual leukocyte subpopulations. In conclusion, the authors come to the conclusion that the use of the proposed method of visualizing multidimensional relationships makes it possible to determine the pathogenetic features of the formation of hypercalcemia in individual cases. At the same time, in the presence of a large database on electronic media, the technique for visualizing multidimensional relationships can be proposed as, at least, as an ‘express’ method for ‘recognizing’ different ‘images’ in the structure of the electrolyte ratio panel without actually determining osteomarkers and other complex and expensive methods for the determination of analytes that reflect osteoexchange.