Affiliation:
1. ‘Russian Medical Academy of Continuous Professional Education’ of the Ministry of Healthcare of the Russia
Abstract
Over the past 30 years, assisted reproductive technologies (ART) have developed signifcantly, despite this, not every woman gets a long-awaited pregnancy on her frst attempt at in vitro fertilization (IVF). Not only the quality of gametes is important for successful embryo implantation, but also the readiness of the endometrium for nidation. Dysbiosis of the uterine microbiome can interfere with the necessary physiological changes of the endometrium in the dynamics of the menstrual cycle, reducing the success rate of ART programs. Endometrial structure mismatch with embryonic development leads to an implantation window shift, which together with uterine microbiome changes is one of the causes of recurrent implantation failures (RIF). In recent years, to improve the effectiveness of ART programs, increasing attention has been paid to the study and preparation of the endometrium for embryo transfer. High-throughput sequencing and analysis of the variable regions of the 16S ribosomal RNA gene is a rapid and affordable diagnostic tool that allows identifcation of culturable and non-culturable microorganisms. The debate about the need for treatment of chronic endometritis (CE), becomes more relevant when considering the prevalence of CE (21% among RIFs). The use of matrix RNA sequencing from endometrial tissue sample cells (RNA-seq) as an additional diagnostic method for RIF causes can help in personalized embryo transfer. This can increase the chances of successful implantation. RIF of endometrial origin is a complex problem of modern reproductive medicine. Currently, there is no consensus on the role of the listed endometrial factors of RIF. Receptive endometrium is one of the determinants of successful implantation. However published studies are insuffcient to reasonably recommend the wide application of methods for diagnosis and treatment of such endometrial factors as uterine microbiome changes and implantation window displacement.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference50 articles.
1. Ruiz-Alonso M., Valbuena D., Gomez C., Cuzzi J., Simon C. Endometrial Receptivity Analysis (ERA): data versus opinions. Hum. Reprod. Open.– 2021.– Vol. 00(0).– P. 1–11. https://doi.org/10.1093/hropen/hoab011
2. Moustafa S., Young S.L. Diagnostic and therapeutic options in recurrent implantation failure [version 1; peer review: 2 approved]. F1000Research.– 2020.– Vol. 9.– Art. ID: 208. https://doi.org/10.12688/f1000research.22403.1
3. Rossijskaya Associaciya Reprodukcii Cheloveka. Registr VRT. Otchyot za 2020 god.– SPb: RARCh, 2022.– 56 s. (in Russ.). https://www.rahr.ru/d_registr_otchet/RegistrVRT_2020.pdf
4. Zhenskoe besplodie: Klinicheskie rekomendacii 2021–2022–2023 (24.06.2021): utv. MZ RF (in Russ.). https://moniiag.ru/wp-content/uploads/2019/07/Klinicheskie-rekomendatsii.-ZHenskoe-besplodie.pdf
5. Orazov M.R., Orexov R.E., Kamillova D.P., Silant’eva E.S., Mixalyova L.M., Melexina I.D. Tajny patogeneza povtornyx neudach implantacii.– 2020.– Т. 18, № 4.– S. 43–48 (in Russ.). https://doi.org/10.24411/2074–1995–2020–10030
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献