Cognitive function status in polymorbid patients with arterial hypertension, atrial fibrillation and chronic kidney disease

Abstract

Background. Cognitive impairment is a public health problem. Polymorbid patients with arterial hypertension (AH), atrial fibrillation (AF), and chronic kidney disease (CKD) are at high risk of developing cognitive impairment, resulting in impaired quality of life, difficulty in medication adherence, and increased risk of mortality.Objective. To evaluate the cognitive status of polymorbid patients aged 60 years and older with essential AH and FP depending on the presence and stage of CKD.Materials and methods. 165 patients aged 60 years and older with essential AH and AF (80 [48.5 %] men, 85 [51.5 %] women, mean age was 82 [76; 85] years) were included and divided into three groups depending on the presence and stage of CKD: 55 (33.3 %) patients with AH and AF without CKD, 55 (33.3 %) patients with AH, AF, and CKD C 3a, and 55 (33.3 %) patients with AH, AF, and CKD C 3b. All patients included in the present study were examined for cognitive functions using a series of neuropsychological tests.Results. In the study of cognitive functions (Mini-mental State Examination, MMSE, Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog), Digit Symbol Substitution Test (DSST), literature Association Test), it was found that the severity of cognitive impairment increased with increasing stage of CKD.Conclusions. The obtained results of the study indicate an unfavorable effect of CKD on cognitive functions in elderly and elderly patients with AH and FP. Thus, there is a need for regular monitoring and examination of patients with concomitant CKD for cognitive impairment.