Pathogenetic and prognostic aspects of interleukin‑1-alfa involvement in inflammatory reactions in hemorrhagic stroke

Abstract

Aim of the study. To reveal the pathogenetic and prognostic significance of disturbances in the content of interleukin‑1-alpha (IL‑1α) in the blood serum and cerebrospinal fluid (CSF) of patients in the acute period of hemorrhagic stroke (HI).Materials and methods. In 100 patients with HI (50 men and 50 women aged 58.25 ± 12.43 years), the level of IL‑1α in blood serum and CSF was monitored on the 1st, 3rd and 10th days of the disease by enzyme immunoassay with a set of reagents from Cytokin (St. Petersburg, Russia).Results. From the first day of stroke the content of IL‑1α in blood serum and CSF is 25–30 times higher than the level of healthy individuals, reaches peak values on the third day and slightly decreases by the tenth day of illness.Conclusions. The pathogenetic significance of an increase in the content of IL‑1α in the acute period of hemorrhagic stroke is determined by its participation in the reactions of local and systemic inflammation that accompanies brain damage. The level of IL‑1α can serve as an early marker of the risk of death in patients with GI.