Case of severe liver damage in 12‑year‑old child with intentional overdose of paracetamol

Abstract

Currently, more than 1200 drugs of almost all pharmacological classes are known that can cause drug-induced liver injury (DILI). Antibacterial agents are responsible for almost half (45 %) of all DILI. In second place are psychotropic drugs and analgesics-antipyretics. And if DILI caused by antimicrobial drugs are unintentional and usually the result of an underestimation of drug pathology by doctors, then liver damage that occurs after taking psychotropic drugs or antipyretic analgesics, among which paracetamol stands out, is often the result of their deliberate use for suicidal purposes against the background of depression both in adults and in adolescents 12–17 years of age.