Practical aspects of biological drug therapy in ankylosing spondylitis’ patient

Abstract

The clinical picture of the ankylosing spondylitis (AS) is quite diverse. Extra-articular manifestations such as eye involvement (uveitis), damage of the aorta (aortitis), aortic valve insufficiency, inflammatory bowel disease, IgA nephropathy are often observed alongside with the damage of the musculoskeletal system. Since the course of AS is characterized by the significant variability the therapy of the patient requires an individualized strategy, depending on the predominant clinical manifestation. In this article we have considered development of the clinical features and disease progression in patient with AS as well as have analyzed and discussed the difficulties in AS pts treatment. Optimal treatment in case of the primary resistance to conventional drugs and the following failure of two drugs belonging to the biological agents is of a special interest in this case.