Average molecular weight levels in patients with myocardial infarction against COPD depending on presence of complications in acute period

Abstract

Purpose. To study the levels of average molecules in patients with myocardial infarction against the background of chronic obstructive disease depending on the presence of complications in the acute period of the infarction.Materials and methods. We studied 225 patients with STEMI. In 195 of them the MI developed against the background of COPD, and in 130 of them it was mono-inflammatory. Among mono-nososologic patients there were 85 patients with acute MI without any complications and 45 patients with complications. Among patients with COPD, 62 patients had uncomplicated MI, and 133 had complicated MI. The comparison group consisted of 110 somatically healthy individuals. Average molecules were determined according to M. Ya. Malakhova (1995) method by direct spectrometry. Statistical data processing was performed using SPSS 26.0 software package.Results of the study. The levels of LMWP and OP in various biological fluids in patients with complicated MI were statistically significantly higher both among patients with MI as a mononosomal disease and in the presence of COPD. Patients with complications registered higher levels of catabolic pool, endogenous intoxication index and lower values of intoxication coefficient. Among MI patients without complications stage I of endogenous intoxication prevailed, and among the patients with complicated MI and with uncomplicated MI against COPD – stage II, and among the patients with complicated MI against COPD – stage III.Conclusion. Complicated myocardial infarction is characterized by more pronounced endogenous intoxication. In comorbid patients with complicated MI, endogenous intoxication is more pronounced than in complicated MI without COPD. The demonstrability of the LMWP and OP levels allows us to recommend their use in prognostic algorithms for the development of coronary pathology in comorbid patients.