Current representations about etiological factors in development of delayed puberty in children with inherited epidermolysis bullosa

Abstract

Inherited epidermolysis bullosa is distinguished by a wide range of clinical manifestations: from single blisters and erosions, mainly with acral localization, which insignifcantly affect the quality and life expectancy of patients with a mild course of the disease, to severe disabling forms with a high mortality rate from multifactorial malnutrition, septicemia in early age and high risk of developing squamous cell carcinoma of the skin in adult patients. According to research studies, in children suffering from chronic diseases, there is often a delay of puberty. To date, there are no reliable data on the incidence of delayed puberty in children with inherited epidermolysis bullosa, which is of interest for further research in order to more individualized approach to treatment and improve the quality of life of patients.