Myeloperoxidase, troponin I and C-reactive protein in blood of patients before and after coronary artery bypass grafting

Abstract

   The study of dynamics of laboratory markers before and after heart surgery makes it possible to predict the risks of postoperative complications. Troponin I is ‘the gold standard’ for diagnosing acute myocardial infarction, but with an increase in the marker after heart surgery, the interpretation of the results can be difficult. Therefore, the search for new combinations of laboratory markers can help in assessing the degree of myocardial damage after surgery, as well as the risk of complications. Myeloperoxidase as a new laboratory indicator is of interest, since there are many studies on the prognostic value of an increase in this marker in patients with coronary heart disease in the development of cardiovascular complications. In the present study, the dynamics of myeloperoxidase, troponin I, and C-reactive protein in patients (n = 60) with a confirmed diagnosis of coronary heart disease before and after elective coronary artery bypass grafting under cardiopulmonary bypass was assessed. The following results were obtained: an increased level of myeloperoxidase in blood plasma in patients before surgery is an additional indicator in assessing the risk of postoperative complications, regardless of the concentration of C-reactive protein. A correlation was found between the concentration of troponin I and the level of myeloperoxidase in the blood, as well as between the duration of cardiopulmonary bypass and the level of MPO 24 hours after surgery.