Affiliation:
1. Russian National Research Medical University n.a. N.I. Pirogov
Abstract
The review discusses issues related to genetic predisposition and resistance to tuberculosis. Genetic factors largely determine susceptibility to various diseases, including infections. The main focus is on the genes of the major histocompatibility complex and toll-like receptors. A number of genetic polymorphisms responsible for resistance and predisposition to tuberculosis and related clinical consequences are considered. Knowledge of molecular genetic biomarkers is necessary to identify risk groups and carry out predictive measures.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference13 articles.
1. Matzaraki V., Kumar V., Wijmenga C. et al. The MHC locus and genetic susceptibility to autoimmune and infectious diseases, // Genome Biol.– 2017.–18.– 1.– 76.
2. Bai X., Wilson S.E., Chmura K. et al. Morphometric analysis of Th(1) and Th(2) cytokine expression in human pulmonary tuberculosis.// Tuberculesis (Edinb.).– 2004.– 84.– 6.–P. 375–385.
3. Archakova L.I., Skvortsova L.A., Knoring B.E. and other Immunogenetic aspects of the course and treatment of pulmonary tuberculosis. // Problems of tuberculosis and lung diseases.– 2008.– No. 12.– P. 34–37.
4. Skvortsova L.A., Pavlova M.V., Kondakova M.N. The role of the HLA-DRB1* genotype in the complex therapy of respiratory tuberculosis / L.A. Skvortsova, T.I. Vinogradova, R.G. Kovaleva, L.I. Archakova // Problems of tuberculosis and lung diseases.– 2008.– No. 12.– P. 38–40.
5. Azad A.R., Sadee W., Schlesinger L.S. Innate Immune Gene Polymorphisms in Tuberculosis// Infect. Immun.– 2012.– 80.– 10.– P. 3343–3359.
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