Affiliation:
1. St. Petersburg State Chemical and Pharmaceutical University
2. National Medical Research Centrу for Pediatric Traumatology and Orthopedics n. a. G. I. Turner
Abstract
This paper presents the results of an expert analysis of laboratory data of patients with pathology of the musculoskeletal system, obtained using an expert analytical system. The personal data of patients who had the index of N-telopeptide of type I collagen molecules (TP1NP) were analyzed. The complex of TP1NP connections in personal observations was established by comparing the structural features of the formation of a panel of ratios of indicators of water-electrolyte metabolism against the background of the dynamics of the analyzed osteomarkers. At the same time, two types of influence of TP1NP growth on the ‘final’ structure of the panel of electrolyte ratios were singled out from the general array and personally analyzed – a high influence of the complex of TP1NP-associated bonds at the intersystem level and at absolute values of TP1NP that go beyond > M + G. A detailed analysis of the recorded relationships is presented with the substantiation of the leading mechanisms for the formation of TP1NP-associated complexes using literary sources. The authors come to the conclusion that under conditions of ‘disturbing’ effects on the body, a pronounced reaction can be achieved, in particular, due to mutual multiplication (multiplication) of the effectiveness of various mechanisms without pronounced shifts in the absolute values of the analyzed indicator. At the same time, the increase in the quantitative indicator of TP1NP with a weak expression of its effect on the final structure of the panel of electrolyte ratios may correspond to the predominant effect on bone metabolism of other factors that go beyond the osteomarkers analyzed in the article, thereby determining the need to continue the search and deciphering different complexes. At the same time, the observations presented and analyzed in this work, which demonstrate a high degree of influence on the integral PSE of the TP1NP-associated complex, can be entered into the archive of the knowledge base and recognized in the routine interpretation of the obtained laboratory data on water-electrolyte metabolism.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
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