Multitarget therapy in patients with GERD and obesity

Abstract

The article presents the results of a clinical study involving 59 overweight or obese patients with gastroesophageal reflux disease. Non-erosive reflux disease was diagnosed in 30 (51%), erosive esophagitis A (Los Angeles endoscopic classification) in 29 (49%) patients. The severity of the main symptoms of GERD was assessed, physical examination, esophagogastroduodenoscopy, daily pH impedance monitoring of the upper gastrointestinal tract, psychometric testing were performed. The body mass index correlated with age (0.35); the presence of a diaphragmatic hernia (0.32); cough (0.35); pH in the stomach (0.30); the number of slightly alkaline gastroesophageal refluxes (0.32); slightly alkaline time in the esophagus in minutes (0.30) and percent (0.32); reactive anxiety (0.30), number of points of FF scale (–0.26) and MH scale of the SF-36 questionnaire (–0.25). Waist circumference correlated with the presence of erosive esophagitis (0.25); male sex (0.32); diaphragm hernia of (0.40); duodenogastric reflux (0.42); DeMeester index (0.31), the duration of the longest acid gastroesophageal reflux (0.25). Patients with erosive esophagitis compared with patients with non-erosive reflux disease more often consumed alcohol; had higher BMI; more often had epigastric pain and oral bitterness, longer bolus time in the esophagus and poorer quality of life according to the MH scale of the SF-36 questionnaire. Taking into account the revealed features of pathogenesis, the drugs of choice in the treatment of GERD in overweight and obese patients may be multitarget molecules of itopride hydrochloride (Itomed®), ursodeoxycholic acid (Ursosan®) and rebamipid (Rebagit®).