Affiliation:
1. Moscow Scientific and Practical Centre for Dermatovenereology and Cosmetology
2. Moscow State University n. a. M. V. Lomonosov
3. Moscow State University n. a. M. V. Lomonosov; Russian University of Chemical Technology n. a. D. I. Mendeleev
Abstract
Modern therapeutic views on the pathogenesis of acne indicate the role of permanent inflammation and expand the arsenal of medicines and combined techniques necessary for the successful treatment of this chronic skin disease. The complex process of immune inflammation in acne with the participation of pro-inflammatory cytokines is due to the interaction of trigger factors and factors of innate immunity. It was found that C. acne is able to interact with markers of increased immunity, such as Toll-like and protease-activated receptors. Based on a detailed analysis of the literature in search systems like PubMed, eLibrary.ru, CyberLeninka, it was found that one of the key roles in inflammation in acne belongs to matrix metalloproteinases. Thus, C. acnes are involved in many processes in the pathogenesis of acne, including inflammation, hyperkeratosis and hyperproduction of sebum, which necessitates its eradication and is an important component of complex therapy. Minocycline (Minolexin) is a highly effective drug for the treatment of moderate to severe forms of acne, including a low-dose regimen, and is included in the European Treatment Guidelines. Minocycline is considered the most powerful inhibitor of MMP, has a pronounced anti-inflammatory effect and a high level of lipophilicity, quickly penetrates the lipid layer of the bacterium and intensively accumulates in the sebaceous glands.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference21 articles.
1. Acne and rosacea. Edited by L. S. Kruglova 2021. 207 p.
2. Goryachkina M. V. The role of psycho-emotional factors in the development of acne. Dermatology. 2008. No. 2. P. 8–12.
3. Acne and rosacea. Ed. N. N. Potekaeva. M., 2007. 216 p.
4. Pang Y, He CD, Liu Y, Wang KB, Xiao T, Wang YK, Zhu H, Wei B, Zhao N, Jiang Y, Wei HC, Chen HD. Combination of short CAG and GGN repeats in the androgen receptor gene is associated with acne risk in North East China. J Eur Acad Dermatol Venereol. 2008 Dec; 22 (12): 1445–51.
5. Kruglova L. S., Gryazeva N. V., Talybova A. M. Post-acne symptom complex: methods of prevention and therapy. Clinical dermatology and cosmetology. 2020. 19 (5). P. 622–629.
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