Treatment of upper respiratory tract infections: the role of doxycycline

Author:

Pereverzev A. P.1ORCID,Pereverzeva A. S.2ORCID,Kovaleva G. P.3ORCID,Ostroumova O. D.4ORCID

Affiliation:

1. Russian Medical Academy of Continuing Professional Education

2. Peoples’ Friendship University of Russia

3. Sanatorium «Zagorskie dali» of the Administrative Department of the President of the Russian Federation

4. Russian Medical Academy of Continuing Professional Education; First Moscow State Medical University named after I. M. Sechenov

Abstract

Upper respiratory tract infections (URTI) are a large group of infectious diseases (mainly viral and bacterial), affecting the mucous of the nasal cavity, paranasal sinuses, pharynx and larynx. URTI are very common in inpatient and outpatient clinical practice. In this article, we present a clinical case of Patient N., 20 years old, consulted with upper respiratory tract damage caused by Chlamydia pneumoniae. The patient admitted to clinical diagnostic center on 07.07.2021 with complaints of pain in the left maxillary sinus with irradiation to the left temporal region, difficulty in nasal breathing, pain in the pharynx, aggravated by swallowing, and increased body temperature (37,5 °C). The patient was consulted by an interdisciplinary team (ENT doctor and clinical pharmacologist). After carrying out physical, instrumental and laboratory tests the diagnose Chlamydia pneumoniae - associated URTI was established and, the patient was prescribed doxycycline at a dose of 100 mg 2 two times a day on the 1st day following by 100 once a day for the next 6 days with a positive effect. The doxycycline was choisen because of a more favorable safety and efficacy profile compared to fluoroquinolones and some other antibacterial agents. After 7 days of treatment, the patient recovered completely. Among all doxycycline drugs available on the market of the Russian Federation, Doxycycline Express (JSC Pharmstandard-Leksredstva) stands out due to its high quality, bioequivalence to the original drug and comfortable regime of use due to the dosage form (dispersible tablets), that increases the patient’s compliance and allows it to be used by some special categories of patients (elderly and senile patients, patients with dysphagia, etc.

Publisher

Alfmed LLC

Subject

Materials Chemistry,Economics and Econometrics,Media Technology,Forestry

Reference63 articles.

1. Dasaraju P. V. and Liu Ch. Infections of the Respiratory System (Chapter 93) in: Medical Microbiology (ed. Baron S.), 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Available at: https://www.ncbi.nlm.nih.gov/books/NBK8142/ (data obrashcheniya: 14.07.2021).

2. Eccles R. Understanding the symptoms of the common cold and influenza. Lancet InfectDis. 2005;5(11):718-725. doi:10.1016/S 1473-3099(05)70270-X

3. The Merck Manual. Sore throat. Accessed April 2013. Available at: http://www.merckmanuals (data obrashcheniya: 14.07.2021). https://www.msdmanuals.com/professional/ear,-nose,-and-throat-disorders/approach-to-the-patient-with-nasal-and-pharyngeal-symptoms/sore-throat]

4. Reveiz L., Cardona A. F. Antibiotics for acute laryngitis in adults. Cochrane Database Syst Rev. 2015;2015(5): CD 004783. Published 2015 May 23. doi:10.1002/14651858.CD004783.pub5

5. Klinicheskie rekomendatsii «Ostryi sinusit». ID: KR313.2016. Available at: http://www.fesmu.ru/SITE/flles/editor/flle/fpk_pps/rv].pdf (data obrashcheniya: 14.07.2021). [Clinical guidelines «Acute sinusitis». ID: KR313. 2016. Available at: http://www.fesmu.ru/SnE/flles/editor/flle/fpkjpps/rv1.pdf (date accessed: 14.07.2021) (In Russ.).]

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