Affiliation:
1. First Moscow State Medical University n. a. I. M. Sechenov
2. Higher Medical School
Abstract
21-hydroxylase deficiency is the most common genetically determined adrenal steroidogenesis defect. One of the consequences of the disease developing as a result of this defect, congenital dysfunction of the adrenal cortex (CDAC), is a decrease in fertility in the form of infertility or early pregnancy loss. The problem of reducing the fertility associated with CDAC is still not overcome due to a lack of understanding of the causes of negative pregnancy outcomes or the origin of infertility with preserved ovulatory function of the ovaries. A likely factor in reducing fertility in patients with CDAC is hyperandrogenism. But attempts at his glucocorticoid therapy have not been clinically successful. Thus, the issues of fertility restoration in women with CDAC are still relevant. At the moment, the only method of preventing the usual miscarriage and other complications of pregnancy in patients with CDAC is the use of progestogens, subject to their early, preconception purpose.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference80 articles.
1. Shmidt A. A., Zamyatnin S. A., Gonchar I. S., Korovin A. E., Gorodnyuk I. O., Kotsur A. V. Epidemiologiya besplodiya v Rossii i za rubezhom. Klinicheskaya patofiziologiya. 2019; 25 (1): 9–12.
2. Inhorn MC, Patrizio MC. Infertility around the globe: new thinking on gender, reproductive technologies and global movements in the 21st century. Hum Reprod Update. 2015; 21 (4): 411–426.
3. Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clinical Biochemistry. 2018; 62: 2–10.
4. Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat. World Population Prospects: The 2012 Revision. New York, 2013; 18 p.
5. Tret'yakova O. S., Zadnipryanyi I. V. Giperandrogeniya kak bazis formirovaniya besplodiya i akne u zhenshchin reproduktivnogo vozrasta. Krymskii zhurnal eksperimental'noi i klinicheskoi meditsiny. 2015; 5 (3): 65–71.