Neuropsychiatric features of current COVID-19 pandemic (analysis of foreign publications in 2020)

Abstract

The article presents a review of the scientific literature containing data on the features of neuropsychiatric disorders – complications from the nervous system against the background of viral load caused by SARS-CoV-2 COVID-19. Indirect effects of the virus such as encephalopathy, myopathy, and critical neuropathy can be caused by hypoxia, respiratory and metabolic acidosis, dysregulation of homeostasis due to organ failure, and autoimmune inflammatory and demyelinating processes. Binding to the receptors of APF2, which is a cardiovascular protection factor for various organs, the nervous system and skeletal muscles is a target for various types of coronaviruses, including SARS-CoV-2 can cause an increase in blood pressure- the main risk factor for ONMC. Thus, prospective neuropsychiatric monitoring of people exposed to SARS-CoV-2 at various stages of the life cycle, as well as their neuroimmune status, is necessary to fully understand the long-term impact of COVID-19 and to provide a basis for integrating psychoneuroimmunology into epidemiological studies of pandemics.