Affiliation:
1. Russian National Research Medical University n. a. N. I. Pirogov
2. People’s Friendship University of Russia
Abstract
The review addresses issues related to genetic predisposition and resistance to sexually transmitted infections (STI). Genetic factors largely determine the susceptibility of the body to various diseases, including infectious ones. The main influence is given to the genes of the main histocompatibility complex and toll-like receptors. Some STI and genetic polymorphisms responsible for resistance and susceptibility to infections and related clinical consequences are considered. Knowledge of molecular genetic biomarkers is necessary to identify risk groups, conduct predictive measures, in particular vaccination.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference22 articles.
1. Ojesina A. I., Lichtenstein L., Freeman S. S., et al. Landscape of genomic alterations in cervical carcinomas. // Nature. – 2014. –506. – P. 371–375.
2. Chen D., McKay J.D., Clifford G. et al. Genome-wide association study of HPV seropositivity. // Hum Mol Genet. – 2011. – 20. – P. 4714–4723.
3. Okuyama N. C.M., Cezar-Dos-Santos F., Pereira É. R. Genetic variant in CXCL12 gene raises susceptibility to HPV infection and squamous intraepithelial lesions development: a case-control study. // J Biomed Sci. – 2018. – 25. – 1. – 69.
4. Naslednikova I. O., Novitskii V. V., Urazova O. I. i dr. Allel'nyi polimorfizm genov IL-2 i IL-4 pri gerpesvirusnoi infektsii. // Klin. lab. diagnostika. – 2009. – 7. – S. 39–42.
5. Barkhash A. V., Babenko V. N., Voevoda M. I. et al. Association of IL28B and IL10 gene polymorphism with predisposition to tick-borne encephalitis in a Russian population. // Ticks Tick-Borne Dis. – 2016. – 7. – P. 808–812.