Impaired liver function in first half of pregnancy in practice of obstetrician-gynecologist

Abstract

The article discusses the most common non-infectious liver pathology that complicates the course of the first half of pregnancy. Supraphysiological increase in sex hormone levels and exogenous hormonal effects when using assisted reproductive technologies contribute to the early manifestation of intrahepatic cholestasis in pregnant women and can cause liver damage in the first half of pregnancy. Non-alcoholic fatty liver disease during pregnancy is the most common cause of an unexplained increase in hepatic transaminases. An increase in liver transaminases before pregnancy and in its early stages is associated with the development of preeclampsia and perinatal complications. Safe hepatotropic drugs in the first half of pregnancy include ursodeoxycholic acid, essential phospholipids and solutions of low molecular weight sugars.