Affiliation:
1. All-Russian Centre for Emergency and Radiation Medicine n. a. A. M. Nikiforov
Abstract
The classic function of vitamin D is to regulate calcium metabolism. Currently, however, convincing data have been obtained on the relationship of vitamin D deficiency with the development of a number of diseases. The article analyzes the results of recent studies that present the effects of vitamin D on the immune system, cardiovascular system and liver diseases. Discusses the mechanisms of admission of vitamin D in the body, presents new data on the regulation of levels of active form of vitamin D phosphatonins (FGF23, MEPE, sFRP-4) and protein Klotho. The characteristic of methods of determination of vitamin D in blood serum is presented. Biological factors that influence the results of quantitative determination of vitamin D with different methods are considered separately.
Subject
Materials Chemistry,Economics and Econometrics,Media Technology,Forestry
Reference31 articles.
1. Defitsit vitamina D u vzroslykh: diagnostika, lechenie, primenenie. Klinicheskie rekomendatsii. – M., 2015. – 75 s.
2. Zhilyaev E. V. Klinicheskoe znachenie narusheniya kal'tsievogo obmena /E.V. Zhilyaev, A. V. Glazunov, P. A. Glazunov // Klin. meditsina. – 2011. – № 4. – S. 13–17.
3. Snopov S. A. Mekhanizmy deistviya vitamina D na immunnuyu sistemu / Meditsinskaya immunologiya. – 2014. – T. 16, № 6. – S. 499–530.
4. Abdel-Wareth L. Total vitamin D assay comparison of the Roche Diagnostics “Vitamin D total” electrochemiluminescence protein binding assay with the Chromsystems HPLC method in a population with both D 2 and D 3 forms of vitamin D / L. Abdel-Wareth, A. Haq, A. Turner, S. Khan, A. Salem, F. Mustafa, N. Hussein, F. Pallinalakam, L. Grundy, G. Patras, J. Rajah // Nutrients – 2013. – Vol. 22, T. 5. – N 3. – P. 971–980; DOI: 10.3390/nu5030971.
5. Atef S. H. Vitamin D assays in clinical laboratory: Past, present and future challenges / S. H. Atef // www.ncbi.nlm.nih.gov/pubmed/28242262–2018/ – T. 175. P. 136–137; DOI: 10.1016/j.jsbmb.2017.02.011.