The features of the pollen sensitization in seasonal allergic rhinitis patients with gastrointestinal tract inflammatory diseases comorbidity

Abstract

BACKGROUND:Allergic diseases and gastrointestinal tract diseases can influence on the natural course of each other. AIM:To study the sensitization profile in patients with comorbidity of seasonal allergic rhinitis (SAR) and upper gastrointestinal tract inflammatory diseases (UGITID). MATERIALS AND METHODS:112 adult residents of Volgograd city suffering from SAR but without perennial symptoms and sensitization to indoor allergens have been included in the study. 31/112 patients hadH. pylori-negative and 38/112 H. pylori-positive UGITID. Control group consisted of 43/112 patients without gastrointestinal diseases. Skin prick-testing with 3 groups of pollen allergens have been carried out. RESULTS:75.9% of patients were sensitized to weed pollen; sensitization to grass pollen was in 1.53 times less, and 10.5% of patients (4/38) had positive tests with birch pollen. The sensitization to quinoa and ragweed in SAR and H. pylori-UGITID patients was comparable with control group but less common with wormwood, sumpfweed allergens. The sensitization in SAR patients andH. pylori+-UGITID was similar to the control group, but positive SPT with sunflower and corn allergens were rare then in control group. CONCLUSION:Weed pollen allergens prevail in sensitization spectrum of adult Volgograd residents with SAR. Sensitization to goose-foot and ragweed is common less in SAR patients andH. pylori-UGITID but to graminea grass and birch pollen is more often. It may be supposed that the UGITID are predisposing factors to the sensitization to cross-reacting plant food allergens. At the same time supposed immunomodulating action ofH. pylorimake the differences between AR patients withH. pylori+-UGITID orH. pylori-UGITID minor.