Abstract
The article presents the current understanding of the genomic and nongenomic mechanisms of action of glucocorticoids, outlined data which cast doubt on the assertion of the positive role of nongenomic effects of this group of drugs for the treatment of patients suffering from atopic dermatitis, and the necessity of further experimental and clinical studies of corticosteroids with regard to the mechanisms of their action. Reasoned application of topical corticosteroids that have proven a high index of efficacy/safety with a wide range of dosage forms, which allows to optimize therapy for a particular patient.