Abstract
The paper has given an insight of allergy as evolutionary selected reactivity for highly organized animals. This reactivity is directed to organization of allergen-specific inflammation and serves as biologically expedient, high-specific and high-sensitive reaction in response to allergen entering into the organism because of barrier tissue dysfunction (higher allergen permeability). such insight has raised a question on consequences of allergy reactivity elimination for highly organized animals and their posterity.
Reference65 articles.
1. Гущин И.С., Курбачева О.М. Аллергия и аллергенспецифическая иммунотерапия. М., «Фармарус Принт». 2010, 228 с.
2. Burton O.T., Oettgen H.C. Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunol. Rev. 2011, v. 24, p. 128-143.
3. Agrawal D.K., Shao Z. Pathogenesis of allergic airway inflammation. Cur. Allergy Asthma Rep. 2010, v. 10, p. 39-48.
4. Wu L.C. Immunoglobulin E receptor signaling and asthma. J.Biol. Chemistry. 2011, v. 23, p.32891-32897.
5. Saito H., Ishizaka T., Ishizaka K. Mast cells and IgE: from history to today. Allergology International. 2013, v. 62, p. 3-12.