CHANGES IN UPPER RESPIRATORY TRACT MICROBIOTA IN PATIENTS WITH RESPIRATORY ALLERGY ON THE BACKGROUND OF SENSITIZATION TO BACTERIAL STAPHYLOCOCCAL SERINE PROTEINASE BEFORE AND AFTER BASELINE AND ALLERGEN-SPECIFIC THERAPY (ASIT)

Abstract

Allergic rhinitis (AR) is a common allergic disease in children and adults, often combined with other allergic diseases. Objective. To study the changes in the local microbiota of the upper respiratory tract (URT) in patients with respiratory allergy in the dynamics of the disease, as well as after therapy, and the possible participation of some components of opportunistic microbiota, in particular, S. aureus in the formation of allergic inflammation. The study included 182 patients with respiratory allergy (seasonal and year-round allergic rhinitis and combined forms with atopic bronchial asthma) aged 6 to 54 years. The study was a case-control study for 5 years. Methods. A complex of microbiologic, immunologic and allergologic methods of research was applied in the course of the study. Results. In patients in remission of allergic rhinitis who received ASIT in the form of SLIT, in contrast to patients who received baseline therapy, we found an increase in the occurrence of commensal staphylococci (S. epidermidis) and a decrease in the occurrence of hemolytic forms of bacteria and Staphylococcus aureus. Conclusions. The formation of sensitization to the bacterial component of staphylococci (serine proteinase of S. aureus - SplA) in seasonal and year-round allergic rhinitis on the background of dysbiosis of the local microbiota of the mucous membrane of the respiratory tract and nasopharynx has been established.