Process optimization of preparation of pentoxifylline – extended release tablets

Abstract

The possibilities for correction of the rate of drug release by minimal changes in the technology process and by maintaining the quantitative and qualitative composition of the product pentoxifylline – extended release tablets were explored. Correction was made by addition of different quantity of HPMC (4000 cPs) to a granulating solution of PEG 6000. The main characteristics of the granules (compressibility index and density) were established. The swelling of the hydrogel tablets in water was determined in order more information on the release process to be obtained. Dissolution profiles of produced tablets were determined.